Fluocinolon Therapy Induced Oxidative Stress on Pregnant Rat Adrenal, Pancreas and Liver

It has been established that topical glucocorticoids, widely used for dermatological treatments, have a high rate of transcutaneous penetration and once absorbed into systemic circulation they produce unwanted secondary systemic side effects. As resulted from our preliminary experiments a short-term epicutaneous treatment with Fluocinolonacetonid N in various age groups of rats induces structural and ultrastructural modifications of some organs accompanied by several biochemical disorders. In recent studies elsewhere we have reported that the short-term and long-term epicutaneouse applications of halogenated glucocorticosteroids in pregnant rats induced changes of thymus oxidative status of dams and newborn animals. Starting from the above observations and from the important physiological roles of some glands in the embryological development of the organism, we investigated the Fluocinolon therapy induced oxidative stress on pregnant rat suprarenal, hepar and pancreatic glands.